Analytical performance evaluation of bioactive adrenomedullin on point-of-care platform

For matrix comparison, EDTA whole blood samples (freshly collected and stored at 2-8 °C until the testing) from ten healthy donors were spiked with synthetic bio-ADM to achieve two bio-ADM levels per donor spanning the measuring range. The analytical performance evaluation was mainly conducted using frozen and contrived plasma samples and to validate bio-ADM measurements with IB10 sphingotest SP ® sp bio-ADM SP ® sp . Keywords: acute care;bioactive adrenomedullin;critical care biomarker;endothelial function;Nexus IB10;point-of-care platform EN acute care bioactive adrenomedullin critical care biomarker endothelial function Nexus IB10 point-of-care platform e13 e16 4 11/28/22 20230101 NES 230101 To the Editor, Biologically active adrenomedullin (bio-ADM) is a peptide hormone that regulates the endothelial barrier function [[1]], [[2]], [[3]]. [Extracted from the article]

Radio Frequency Heating of Washable Conductive Textiles for Bacteria and Virus Inactivation.

The ongoing COVID-19 pandemic has increased the use of single-use medical fabrics such as surgical masks, respirators, and other personal protective equipment (PPE), which have faced worldwide supply chain shortages. Reusable PPE is desirable in light of such shortages; however, the use of reusable PPE is largely restricted by the difficulty of rapid sterilization. In this work, we demonstrate successful bacterial and viral inactivation through remote and rapid radio frequency (RF) heating of conductive textiles. The RF heating behavior of conductive polymer-coated fabrics was measured for several different fabrics and coating compositions. Next, to determine the robustness and repeatability of this heating response, we investigated the textile's RF heating response after multiple detergent washes. Finally, we show a rapid reduction of bacteria and virus by RF heating our conductive fabric. 99.9% of methicillin-resistant Staphylococcus aureus (MRSA) was removed from our conductive fabrics after only 10 min of RF heating; human cytomegalovirus (HCMV) was completely sterilized after 5 min of RF heating. These results demonstrate that RF heating conductive polymer-coated fabrics offer new opportunities for applications of conductive textiles in the medical and/or electronic fields.

Rapid development of telehealth capabilities within pediatric patient portal infrastructure for COVID-19 care: barriers, solutions, results.

The COVID-19 national emergency has led to surging care demand and the need for unprecedented telehealth expansion. Rapid telehealth expansion can be especially complex for pediatric patients. From the experience of a large academic medical center, this report describes a pathway for efficiently increasing capacity of remote pediatric enrollment for telehealth while fulfilling privacy, security, and convenience concerns. The design and implementation of the process took 2 days. Five process requirements were identified: efficient enrollment, remote ability to establish parentage, minimal additional work for application processing, compliance with guidelines for adolescent autonomy, and compliance with institutional privacy and security policies. Weekly enrollment subsequently increased 10-fold for children (age 0-12 years) and 1.2-fold for adolescents (age 13-17 years). Weekly telehealth visits increased 200-fold for children and 90-fold for adolescents. The obstacles and solutions presented in this report can provide guidance to health systems for similar challenges during the COVID-19 response and future disasters.